At the Antarctica Umbrella base, scientists created a new form of B.O.W. spider, the black widow spider. These hairless, agile spiders were to be transferred to the various Umbrella branches but one of them escaped and grew to an enormous size.

The Giant Black Widow took residence in one of the giant rooms of the Antarctic base. When the base froze, the spider froze along with it; it became stuck in a giant ice cube. Chris found the giant spider and had to break the ice holding it in order to move on. The Giant Black Widow tried to eat Chris but he quickly disposed of the creature.