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Sergei
During his
brief encounter with Wesker on the Umbrella Caucasus Research
Facility, Sergei injected himself with an advanced strain of the
T-virus, converting him into a Tyrant with exposed skull and his
arms fused into one large tentacle.
He was able to retain his memories and speech ability.

Wesker theorised that the mutation Sergei underwent was
unfluenced by the host's mindset. Sergei mutated into a monster
that, according to him, is the picture of his true personality:
a man who suffered in the inside.
Games:
Biohazard
Umbrella Chronicles
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