Even after the mansion incident ended, the “cannibal disease” (T-virus) had spread to Raccoon City, plunging it into a state of panic. The city was quarantined, while R.P.D. officers and U.B.C.S. soldiers attempted to rescue its citizens. The situation grew more and more desperate, and the possibility of the virus spreading beyond the quarantine was growing. The U.S. government was concerned and called a nationwide conference to discuss the next step.

They formulated a plan for the complete eradication of the city. In compliance, on October 1st, 1998, the military launched a new type of strategic missile into the heart of the city. Raccoon City, with its 100,000 inhabitants, was forever wiped from the face of the earth.