James Marcus was the first head of Umbrella’s Management Training Facility. A founding member of Umbrella Corporation and one of the pioneers who discovered the Progenitor virus, he was so involved in his research he began to use Umbrella employees as test subjects in his experiments. The number of sacrifices totaled nearly 20 people. Acting under special orders from Ozwell E. Spencer, Albert Wesker and William Birkin assassinated Dr. Marcus in 1988. However, 10 years after his death, he was mysteriously revived. To exact his revenge, he began secret activities with the goal of destroying not only Umbrella, but the entire world.